Modification of the Drosophila model of in vivo Tau toxicity reveals protective phosphorylation by GSK3b
نویسندگان
چکیده
Giulia Povellato*, Richard I. Tuxworth*, Diane P. Hanger and Guy Tear MRC Centre for Developmental Neurobiology, King’s College London, New Hunt’s House, Guy’s Hospital Campus, London SE1 1UL, UK School of Clinical and Experimental Medicine, University of Birmingham, The Medical School, Birmingham B15 2TT, UK Department of Neuroscience, King’s College London, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
منابع مشابه
Modification of the Drosophila model of in vivo Tau toxicity reveals protective phosphorylation by GSK3β
Hyperphosphorylation of the microtubule associated protein, Tau, is the hallmark of a group of neurodegenerative disorders known as the tauopathies which includes Alzheimer's disease. Precisely how and why Tau phosphorylation is increased in disease is not fully understood, nor how individual sites modify Tau function. Several groups have used the Drosophila visual system as an in vivo model to...
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The microtubule-associated protein Tau is found in large amount in axons of neurons and is involved in human neurodegenerative diseases called tauopathies, which include Alzheimer's disease. In these diseases, the Tau protein is abnormally hyperphosphorylated and one therapeutic strategy currently under consideration consists in inhibiting Tau phosphorylation. However, the consequences of an ex...
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Hyperphosphorylation of tau at multiple sites has been implicated in the formation of neurofibrillary tangles in Alzheimer's disease; however, the relationship between toxicity and phosphorylation of tau has not been clearly elucidated. Putative tau kinases that play a role in such phosphorylation events include the proline-directed kinases glycogen synthase kinase-3beta (GSK-3beta) and cyclin-...
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